Cannabidiol (CBD) oil is one of the hot new product in states which have legalized medical marijuana. The non-intoxicating marijuana extract is being credited with helping treat a number of medical conditions — everything from epileptic seizures to anxiety to inflammation to sleeplessness. But experts say the evidence is scant for most of these touted benefits.
Worse, CBD has been produced without any regulation, leading to items that vary widely in quality, said Marcel Bonn-Miller, an adjunct assistant professor of psychology in psychiatry in the University of Pennsylvania School of Medicine. “It really is the Wild West,” Bonn-Miller said. “Joe Bob who starts up a CBD company could say whatever the hell he wants on a label and then sell it to people.”
Cannabidiol is taken from the flowers and buds of marijuana or hemp plants. It does not produce intoxication; marijuana’s “high” is brought on by the chemical tetrahydrocannabinol (THC). CBD oil is legal in 30 states where medicinal and recreational marijuana is legal, based on Governing magazine.
Seventeen additional states have CBD-specific laws on the books, based on Prevention magazine. Those are Alabama, Georgia, Indiana, Iowa, Kentucky, Mississippi, Missouri, N . C ., Oklahoma, South Carolina, South Dakota, Tennessee, Texas, Utah, Virginia, Wisconsin and Wyoming.
Strong Evidence for Treating Epilepsy – Just one single purported use for go to healthbenefitscannabidiol.com, to deal with epilepsy, has significant scientific evidence supporting it. Last month, a U.S. Food and Drug Administration advisory panel unanimously recommended approval of the CBD medication Epidiolex to take care of two rare forms of childhood epilepsy. “That’s actually the only area in which the evidence has risen to the point in which the FDA has said this is acceptable to approve a new drug,” said Timothy Welty, chair from the department of clinical sciences at Drake University’s College of Pharmacy and Health Sciences, in Des Moines, Iowa.
Throughout CBD’s potential uses, there exists simply too little evidence to make a firm conclusion. As an example, some human clinical trials suggest that CBD may be great at treating signs and symptoms of anxiety, particularly social anxiety, Bonn-Miller said. Here is the potential use for CBD with all the most evidence after usefulness in epilepsy, but “there’s a reliable gap between the two,” he said. “There have been clinical trials in adults, but a great deal smaller than the epilepsy studies which have been completed in kids,” Bonn-Miller said. CBD’s usefulness as an anti-inflammatory medication is the following most promising, but those results come mostly from animal studies, experts said.
Most Other Uses Largely Unproven – The remainder of the potential uses — as being an antipsychotic, antidepressant or sleep aid “have been studied in animals, with only 1 or 2 examples of studies in humans,” Bonn-Miller said. And Welty said the studies that have featured humans for such other CBD uses have either been case reports or studies that failed to compare results against a control group that did not make use of the oil. “There’s no control, so it’s basically how can you tell if we’re working with the real effect from the drug or just simply a placebo effect because somebody thinks they’ve been given a drug that will be beneficial?” Welty said. There also are concerns about both the standard of CBD oil being produced along with its potential side effects, the experts added.
Absence of Regulation Also Concerning – Due to the legally murky nature of marijuana, the FDA has not stepped in to regulate products like CBD oil, Bonn-Miller said. States are struggling to place regulations in position, nevertheless they don’t possess the deep pockets of the federal government. Meanwhile, a 2017 study led by Bonn-Miller learned that nearly 7 of 10 CBD products didn’t contain the amount of marijuana extract promised on the label. Nearly 43 percent in the products contained not enough CBD, while about 26 percent cptgdg too much, Bonn-Miller said.
“CBD is kind of a tricky drug because it’s not so well absorbed orally,” Welty explained. “Lower than twenty percent in the drug is absorbed orally. When it isn’t made in the right way, you may not be getting much drug into your systemic circulation.” Worse, about 1 in 5 CBD products contained the intoxicating pot chemical THC, Bonn-Miller and his colleagues found.
“That’s a difficulty because THC can increase anxiety. It may can even make seizures worse. These are the types of things you should be careful about,” Bonn-Miller said. “Basically If I were a consumer, purchasing it for myself or my kid, I would like to test it so that I knew exactly what it actually had within it, because I couldn’t trust what was on the label,” Bonn-Miller concluded.
Potential Interactions Along With Other Meds – Studies on CBD also have raised concerns about possible interactions with some other drugs. For instance, epilepsy studies found that “there were very clearly increases inside the blood degrees of a few other anti-epileptic drugs when individuals were on CBD,” Welty said.